Prokaryotic and Eukaryotic Cells Escape Room

Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science

“Your best friend’s cells have mutated into the “zombie virus.” The cure is locked away in a nearby location. You must quickly answer these puzzles about prokaryotic and eukaryotic cells to get your hands on the cure. Otherwise, your friend will be doomed to be a brain-eating zombie forever. Don’t waste time – he’s counting on you!”

Immerse your students in a fun, engaging, learning experience with the Prokaryotic and Eukaryotic Cells Science Escape Room! We have created a unique experience that will leave a lasting, positive impression on your students.

  Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science

Standards Covered:

  • TEKS:
    • 6.12 A – Understand that all organisms are composed of one or more cells
    • 6.12 B – Recognize that the presence of a nucleus is a key factor used to determine whether a cell is prokaryotic or eukaryotic
    • 6.12 D– Identify the basic characteristics of organisms, including prokaryotic or eukaryotic, unicellular or multicellular, autotrophic or heterotrophic, and mode of reproduction, that further classify them in the currently recognized Kingdoms
  • NGSS:
    • MS LS1-1- Conduct an investigation to provide evidence that living things are made of cells; either one cell or many different numbers and types of cells
    • MS LS1-2 – Develop and use a model to describe the function of a cell as a whole and ways parts of cells contribute to the function
    • MS LS1-4 – Use argument based on empirical evidence and scientific reasoning to support an explanation for how characteristic animal behaviors and specialized plant structures affect the probability of successful reproduction of animals and plants respectively


Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science

How it works:

Unlike many escape rooms, the teacher is in total control on which of the 8 puzzles they want to use and in which order to use them. They are designed using modules, with each puzzle independent of the others. There are several ways to play the games, so the teacher will need to decide which approach is best for their students. You have the option to do as many or as few of the puzzles as you choose, in any order. This is great for differentiating, and for shorter or longer class periods. We recommend 5-6 puzzles for a 40 minute class period.


  • Break up the class into teams of 2-4 students
  • Play the challenge video provided
  • After deciding how many puzzles to use, give each group a separate manila envelope. Using manila envelopes is the least expensive option. You can also use locks and boxes. Locks are not required to run this escape room, but it can provide a more authentic experience. A lockout hasp will save you from needing to buy multiple boxes per group.
  • The remaining puzzles stay in a different area where students can check them in and out
  • Start the timer!
  • The teacher will check their codes by the students writing them down on the provided answer sheet, or use the digital lock using Google Forms. More details on how to use this electronically are provided in your purchase.
  • Once the students have solved the puzzles, they will open the last envelope containing their prize!

Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science

Materials Needed:

The escape room can be run in several different ways.
1. The least expensive option is to use manila envelopes for the puzzles. All the directions are provided. Each group will also need:
  • All printed materials from the puzzles chosen
  • Manila envelopes (used for each of the puzzles)
  • Brad or brass fastener for decoder

2. For a more authentic escape room, each group will also need the following:

Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science

Included in your purchase:

  • Teacher directions
  • Editable templates for the teacher to modify
  • Detailed answer key for each puzzle
  • Student answer key
  • Digital answer key (Google Form) that is great for 1:1 or Google Classrooms. Replaces paper answer key if you choose, but not necessary
  • Video challenge to set the mood for the challenge
  • 8 unique puzzles with all printable props
  • A list of over 50 ideas for prizes
  • Reward templates
  • 30 unique signs to hold up for the picture at the end (plus, editable template)

Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science

You can purchase the Prokaryotic and Eukaryotic Cells Escape Room here.

A completed bundle of 37 different escape rooms, covering a wide range of standards and concepts is also available. You can purchase the bundle at a 30% discount here, and receive access to each escape room product!

Teachers are sharing their ideas and experiences using hashtags #keslerscience and #scienceescape on Twitter and Instagram, and on the Kesler Science Professional Learning Network on Facebook. See you there!

Prokaryotic and Eukaryotic Cells Escape Room - Kesler Science


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